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SMILES: Cc1nc2n(Cc3ccccc3F)nc(-c3nnc4c(NC(=O)C4(C)C)n3)c2cc1F

InChI Key: InChIKey=JIAWJXIUNJBDCF-UHFFFAOYSA-N

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 258383   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM258383
PNG
(US9505786, 21)
Show SMILES Cc1nc2n(Cc3ccccc3F)nc(-c3nnc4c(NC(=O)C4(C)C)n3)c2cc1F
Show InChI InChI=1S/C21H17F2N7O/c1-10-14(23)8-12-15(17-25-18-16(27-28-17)21(2,3)20(31)26-18)29-30(19(12)24-10)9-11-6-4-5-7-13(11)22/h4-8H,9H2,1-3H3,(H,25,26,28,31)
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US Patent
n/an/a 22n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...

US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair