BDBM258595 US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-methylbenzo[c][1,2]oxaborol-1(3H)-ol::US9493490, D::US9493490, Example 4
SMILES: Cc1c2B(O)OCc2ccc1Oc1ccc(CN)cc1F
InChI Key: InChIKey=ZCITXZXBLWIHHP-UHFFFAOYSA-N
Data: 7 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GST-Rho-associated protein kinase 1 (ROCK1) (Homo sapiens (Human)) | BDBM258595 (US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-m...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | 25 |
Anacor Pharmaceuticals, Inc. US Patent | Assay Description Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern... | US Patent US9493490 (2016) BindingDB Entry DOI: 10.7270/Q2R2109J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GST-Rho-associated protein kinase 2 (ROCK2) (Homo sapiens (Human)) | BDBM258595 (US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-m...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | 25 |
Anacor Pharmaceuticals, Inc. US Patent | Assay Description Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern... | US Patent US9493490 (2016) BindingDB Entry DOI: 10.7270/Q2R2109J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM258595 (US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-m...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9.25 | n/a | n/a | n/a | n/a | n/a | 25 |
Anacor Pharmaceuticals, Inc. US Patent | Assay Description Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern... | US Patent US9493490 (2016) BindingDB Entry DOI: 10.7270/Q2R2109J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase alpha 1 (Homo sapiens (Human)) | BDBM258595 (US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-m...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.01 | n/a | n/a | n/a | n/a | n/a | 25 |
Anacor Pharmaceuticals, Inc. US Patent | Assay Description Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern... | US Patent US9493490 (2016) BindingDB Entry DOI: 10.7270/Q2R2109J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-dependent protein kinase (PKA) (Homo sapiens (Human)) | BDBM258595 (US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-m...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.06 | n/a | n/a | n/a | n/a | n/a | 25 |
Anacor Pharmaceuticals, Inc. US Patent | Assay Description Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern... | US Patent US9493490 (2016) BindingDB Entry DOI: 10.7270/Q2R2109J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C alpha type (Homo sapiens (Human)) | BDBM258595 (US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-m...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >20 | n/a | n/a | n/a | n/a | n/a | 25 |
Anacor Pharmaceuticals, Inc. US Patent | Assay Description Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern... | US Patent US9493490 (2016) BindingDB Entry DOI: 10.7270/Q2R2109J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-adrenergic receptor kinase 1 (Homo sapiens (Human)) | BDBM258595 (US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-m...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >20 | n/a | n/a | n/a | n/a | n/a | 25 |
Anacor Pharmaceuticals, Inc. US Patent | Assay Description Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern... | US Patent US9493490 (2016) BindingDB Entry DOI: 10.7270/Q2R2109J | |||||||||||
More data for this Ligand-Target Pair |