BDBM25912 3-(3-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole-5-sulfonamide::BMC173212 Compound 2h::indole sulfonamide, 8h
SMILES: NNC(=O)c1[nH]c2ccc(cc2c1-c1cccc(Cl)c1)S(N)(=O)=O
InChI Key: InChIKey=RCWSBQCWRNEOFW-UHFFFAOYSA-N
Data: 15 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Carbonic Anhydrase XIV (Homo sapiens (Human)) | BDBM25912 (3-(3-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM25912 (3-(3-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 9.20 | -11.0 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
alpha-Carbonic Anhydrase (Caenorhabditis elegans) | BDBM25912 (3-(3-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 10.1 | -10.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Istanbul University | Assay Description An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol... | Bioorg Med Chem 17: 3212-5 (2009) Article DOI: 10.1016/j.bmc.2009.01.048 BindingDB Entry DOI: 10.7270/Q2MS3R3Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
beta-Carbonic Anhydrase (Candida albicans (Yeast)) | BDBM25912 (3-(3-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University Curated by ChEMBL | Assay Description inhibition of Candida albicans recombinant Nce103 after 15 mins by stopped-flow CO2 hydration assay | Bioorg Med Chem Lett 20: 2508-11 (2010) Article DOI: 10.1016/j.bmcl.2010.02.103 BindingDB Entry DOI: 10.7270/Q23F4PS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic Anhydrase XV (Mus musculus (mouse)) | BDBM25912 (3-(3-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole...) | KEGG GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 53 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 12 (Homo sapiens (Human)) | BDBM25912 (3-(3-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 7 (Homo sapiens (Human)) | BDBM25912 (3-(3-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 72 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 9 (Homo sapiens (Human)) | BDBM25912 (3-(3-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 73 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM25912 (3-(3-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 311 | -8.87 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic Anhydrase VA (Homo sapiens (Human)) | BDBM25912 (3-(3-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 743 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic Anhydrase XIII (Mus musculus (mouse)) | BDBM25912 (3-(3-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 816 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic Anhydrase VB (Homo sapiens (Human)) | BDBM25912 (3-(3-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 844 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 6 (CA-VI) (Homo sapiens (Human)) | BDBM25912 (3-(3-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 5.57E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 4 (Homo sapiens (Human)) | BDBM25912 (3-(3-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 6.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic Anhydrase III (Homo sapiens (Human)) | BDBM25912 (3-(3-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 6.20E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair |