new BindingDB logo
myBDB logout

BDBM26164 2,4-dianilino pyrimidine, 21::3-[(4-{[3-(N-methylacetamido)phenyl]amino}pyrimidin-2-yl)amino]benzamide

SMILES: CN(C(C)=O)c1cccc(Nc2ccnc(Nc3cccc(c3)C(N)=O)n2)c1

InChI Key: InChIKey=HFHXHDRXXOKQKC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26164   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lck


(Mus musculus)
BDBM26164
PNG
(2,4-dianilino pyrimidine, 21 | 3-[(4-{[3-(N-methyl...)
Show SMILES CN(C(C)=O)c1cccc(Nc2ccnc(Nc3cccc(c3)C(N)=O)n2)c1
Show InChI InChI=1S/C20H20N6O2/c1-13(27)26(2)17-8-4-7-16(12-17)23-18-9-10-22-20(25-18)24-15-6-3-5-14(11-15)19(21)28/h3-12H,1-2H3,(H2,21,28)(H2,22,23,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.80E+3n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair