BDBM261650 N-(4-(3-((tert-butyldimethylsilyl)ethynyl)phenyl)thiazol-2-yl)-5-(4-(4-methylpiperazine-1-carbonyl)phenyl)furan-2-carboxamide::US9708279, 27

SMILES: CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc(o1)C(=O)Nc1nc(cs1)-c1cccc(c1)C#C[Si](C)(C)C(C)(C)C

InChI Key: InChIKey=MPMLXLMOARUFPX-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 261650   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ALK tyrosine kinase receptor (L1196M) (Homo sapiens (Human))	BDBM261650 (N-(4-(3-((tert-butyldimethylsilyl)ethynyl)phenyl)t...) Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc(o1)C(=O)Nc1nc(cs1)-c1cccc(c1)C#C[Si](C)(C)C(C)(C)C Show InChI InChI=1S/C34H38N4O3SSi/c1-34(2,3)43(5,6)21-16-24-8-7-9-27(22-24)28-23-42-33(35-28)36-31(39)30-15-14-29(41-30)25-10-12-26(13-11-25)32(40)38-19-17-37(4)18-20-38/h7-15,22-23H,17-20H2,1-6H3,(H,35,36,39)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33.1	n/a	n/a	n/a	n/a	7.5	25
UNIVERSITÁ DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITÈ DE GENÈVE; UNIVERSITÈ CLAUDE BERNARD LYON 1 US Patent					Assay Description GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...				US Patent US9708279 (2017) BindingDB Entry DOI: 10.7270/Q2MC921P
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM261650 (N-(4-(3-((tert-butyldimethylsilyl)ethynyl)phenyl)t...) Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc(o1)C(=O)Nc1nc(cs1)-c1cccc(c1)C#C[Si](C)(C)C(C)(C)C Show InChI InChI=1S/C34H38N4O3SSi/c1-34(2,3)43(5,6)21-16-24-8-7-9-27(22-24)28-23-42-33(35-28)36-31(39)30-15-14-29(41-30)25-10-12-26(13-11-25)32(40)38-19-17-37(4)18-20-38/h7-15,22-23H,17-20H2,1-6H3,(H,35,36,39)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	428	n/a	n/a	n/a	n/a	7.5	25
UNIVERSITÁ DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITÈ DE GENÈVE; UNIVERSITÈ CLAUDE BERNARD LYON 1 US Patent					Assay Description GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...				US Patent US9708279 (2017) BindingDB Entry DOI: 10.7270/Q2MC921P
					More data for this Ligand-Target Pair