BDBM26396 2,4-diamino-5,6-disubstituted pyrimidine, 10::6-[(3R)-3-aminopyrrolidin-1-yl]-3,5-diazatricyclo[9.4.0.0^{2,7}]pentadeca-1(15),2(7),3,5,11,13-hexaen-4-amine::A-943931

SMILES: N[C@@H]1CCN(C1)c1nc(N)nc-2c1CCCc1ccccc-21

InChI Key: InChIKey=SDTRYHWIXVHTLM-GFCCVEGCSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26396   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H4 Receptor (Rattus norvegicus (rat))	BDBM26396 (2,4-diamino-5,6-disubstituted pyrimidine, 10 | 6-[...) Show SMILES N[C@@H]1CCN(C1)c1nc(N)nc-2c1CCCc1ccccc-21 |r| Show InChI InChI=1S/C17H21N5/c18-12-8-9-22(10-12)16-14-7-3-5-11-4-1-2-6-13(11)15(14)20-17(19)21-16/h1-2,4,6,12H,3,5,7-10,18H2,(H2,19,20,21)/t12-/m1/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	3.80	-11.5	n/a	n/a	n/a	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...				J Med Chem 51: 6547-57 (2008) Article DOI: 10.1021/jm800670r BindingDB Entry DOI: 10.7270/Q2KH0KM5
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM26396 (2,4-diamino-5,6-disubstituted pyrimidine, 10 | 6-[...) Show SMILES N[C@@H]1CCN(C1)c1nc(N)nc-2c1CCCc1ccccc-21 |r| Show InChI InChI=1S/C17H21N5/c18-12-8-9-22(10-12)16-14-7-3-5-11-4-1-2-6-13(11)15(14)20-17(19)21-16/h1-2,4,6,12H,3,5,7-10,18H2,(H2,19,20,21)/t12-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	4.70	-11.4	n/a	n/a	n/a	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...				J Med Chem 51: 6547-57 (2008) Article DOI: 10.1021/jm800670r BindingDB Entry DOI: 10.7270/Q2KH0KM5
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM26396 (2,4-diamino-5,6-disubstituted pyrimidine, 10 | 6-[...) Show SMILES N[C@@H]1CCN(C1)c1nc(N)nc-2c1CCCc1ccccc-21 |r| Show InChI InChI=1S/C17H21N5/c18-12-8-9-22(10-12)16-14-7-3-5-11-4-1-2-6-13(11)15(14)20-17(19)21-16/h1-2,4,6,12H,3,5,7-10,18H2,(H2,19,20,21)/t12-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Griffin Discoveries BV Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes				Bioorg Med Chem Lett 22: 461-7 (2011) Article DOI: 10.1016/j.bmcl.2011.10.104 BindingDB Entry DOI: 10.7270/Q2D79BT2
					More data for this Ligand-Target Pair