BDBM267016 Methyl 4-({[4-(3-aminophenyl)-5-chlorothiophen-2-yl]sulfonyl}amino)-2-hydroxybenzoate trifluoroacetate::US9718809, 107

SMILES: COC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2cccc(N)c2)cc1O

InChI Key: InChIKey=XFSVZFOZDUHDTA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 267016   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) (Homo sapiens (Human))	BDBM267016 (Methyl 4-({[4-(3-aminophenyl)-5-chlorothiophen-2-y...) Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2cccc(N)c2)cc1O Show InChI InChI=1S/C18H15ClN2O5S2/c1-26-18(23)13-6-5-12(8-15(13)22)21-28(24,25)16-9-14(17(19)27-16)10-3-2-4-11(20)7-10/h2-9,21-22H,20H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kancera AB US Patent					Assay Description 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/BPase-2) is a bi-functional enzyme that catalyses the formation and degradation of fructo...				US Patent US9718809 (2017) BindingDB Entry DOI: 10.7270/Q28S4RXR
					More data for this Ligand-Target Pair