BDBM269265 (4RS)-1-(((R)-1-(Cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-4-(methoxymethyl)-4-methyl-2-(4-(1-methyl-1H-indazol-5-yl)phenyl)-1H-imidazol-5(4H)-one ::US10413545, Compound 10::US9718813, Compound 10

SMILES: COCC1(C)N=C(N(C[C@@H]2CCN(C2)C(=O)C2CC2)C1=O)c1ccc(cc1)-c1ccc2n(C)ncc2c1

InChI Key: InChIKey=SUCVQCGWVPTXCT-COBFLCELSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 269265   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fatty acid synthase (Homo sapiens (Human))	BDBM269265 ((4RS)-1-(((R)-1-(Cyclopropanecarbonyl)pyrrolidin-3...) Show SMILES COCC1(C)N=C(N(C[C@@H]2CCN(C2)C(=O)C2CC2)C1=O)c1ccc(cc1)-c1ccc2n(C)ncc2c1 |r,c:5| Show InChI InChI=1S/C29H33N5O3/c1-29(18-37-3)28(36)34(17-19-12-13-33(16-19)27(35)22-8-9-22)26(31-29)21-6-4-20(5-7-21)23-10-11-25-24(14-23)15-30-32(25)2/h4-7,10-11,14-15,19,22H,8-9,12-13,16-18H2,1-3H3/t19-,29?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	490	n/a	n/a	n/a	n/a	7.5	25
Janssen Pharmaceutica NV US Patent					Assay Description In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...				US Patent US9718813 (2017) BindingDB Entry DOI: 10.7270/Q2QV3PJB
					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM269265 ((4RS)-1-(((R)-1-(Cyclopropanecarbonyl)pyrrolidin-3...) Show SMILES COCC1(C)N=C(N(C[C@@H]2CCN(C2)C(=O)C2CC2)C1=O)c1ccc(cc1)-c1ccc2n(C)ncc2c1 |r,c:5| Show InChI InChI=1S/C29H33N5O3/c1-29(18-37-3)28(36)34(17-19-12-13-33(16-19)27(35)22-8-9-22)26(31-29)21-6-4-20(5-7-21)23-10-11-25-24(14-23)15-30-32(25)2/h4-7,10-11,14-15,19,22H,8-9,12-13,16-18H2,1-3H3/t19-,29?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...				US Patent US10413545 (2019) BindingDB Entry DOI: 10.7270/Q2H134CB
					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM269265 ((4RS)-1-(((R)-1-(Cyclopropanecarbonyl)pyrrolidin-3...) Show SMILES COCC1(C)N=C(N(C[C@@H]2CCN(C2)C(=O)C2CC2)C1=O)c1ccc(cc1)-c1ccc2n(C)ncc2c1 |r,c:5| Show InChI InChI=1S/C29H33N5O3/c1-29(18-37-3)28(36)34(17-19-12-13-33(16-19)27(35)22-8-9-22)26(31-29)21-6-4-20(5-7-21)23-10-11-25-24(14-23)15-30-32(25)2/h4-7,10-11,14-15,19,22H,8-9,12-13,16-18H2,1-3H3/t19-,29?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research and Development LLC Curated by ChEMBL					Assay Description Inhibition of human full length FASN using [3H]-acetyl-CoA/malonyl-CoA as substrate after 60 mins in presence of NADPH by scintillation proximity ass...				Bioorg Med Chem Lett 28: 2159-2164 (2018) Article DOI: 10.1016/j.bmcl.2018.05.014 BindingDB Entry DOI: 10.7270/Q2FB55FW
					More data for this Ligand-Target Pair
1,5-anhydro-D-fructose reductase (Homo sapiens (Human))	BDBM269265 ((4RS)-1-(((R)-1-(Cyclopropanecarbonyl)pyrrolidin-3...) Show SMILES COCC1(C)N=C(N(C[C@@H]2CCN(C2)C(=O)C2CC2)C1=O)c1ccc(cc1)-c1ccc2n(C)ncc2c1 |r,c:5| Show InChI InChI=1S/C29H33N5O3/c1-29(18-37-3)28(36)34(17-19-12-13-33(16-19)27(35)22-8-9-22)26(31-29)21-6-4-20(5-7-21)23-10-11-25-24(14-23)15-30-32(25)2/h4-7,10-11,14-15,19,22H,8-9,12-13,16-18H2,1-3H3/t19-,29?/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.12E+3	n/a	n/a	n/a	n/a	7.5	25
Janssen Pharmaceutica NV US Patent					Assay Description 10 μL assay buffer (100 mM KH2PO4 pH 7.5) was added to a 384-well clear plate (costar 3702). 0.3 μL compound (at concentrations of 30 μ...				US Patent US9718813 (2017) BindingDB Entry DOI: 10.7270/Q2QV3PJB
					More data for this Ligand-Target Pair