BDBM269450 (E)-2-(2- isopropylphenyl)-3-(4- (2-(5-methyl-4H-1,2,4- triazol-3- yl)vinyl)phenoxy)benzo [b]thiophen-6-ol::US10058534, 105

SMILES: CC(C)c1ccccc1-c1sc2cc(O)ccc2c1Oc1ccc(\C=C\c2nnc(C)[nH]2)cc1

InChI Key: InChIKey=DWKXPLMQTDGQRW-XNTDXEJSSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 269450   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Estrogen receptor (Homo sapiens (Human))	BDBM269450 ((E)-2-(2- isopropylphenyl)-3-(4- (2-(5-methyl-4H-1...) Show SMILES CC(C)c1ccccc1-c1sc2cc(O)ccc2c1Oc1ccc(\C=C\c2nnc(C)[nH]2)cc1 Show InChI InChI=1S/C28H25N3O2S/c1-17(2)22-6-4-5-7-23(22)28-27(24-14-11-20(32)16-25(24)34-28)33-21-12-8-19(9-13-21)10-15-26-29-18(3)30-31-26/h4-17,32H,1-3H3,(H,29,30,31)/b15-10+	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.4	25
Novartis AG US Patent					Assay Description Plate MCF7 cells at 0.3 million cells/mL (100 l/well) in black, clear-bottom 96-well plates (Greiner, catalog number 655090) in DMEM/F12 media (Gibco...				US Patent US10058534 (2018) BindingDB Entry DOI: 10.7270/Q2M32XSG
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM269450 ((E)-2-(2- isopropylphenyl)-3-(4- (2-(5-methyl-4H-1...) Show SMILES CC(C)c1ccccc1-c1sc2cc(O)ccc2c1Oc1ccc(\C=C\c2nnc(C)[nH]2)cc1 Show InChI InChI=1S/C28H25N3O2S/c1-17(2)22-6-4-5-7-23(22)28-27(24-14-11-20(32)16-25(24)34-28)33-21-12-8-19(9-13-21)10-15-26-29-18(3)30-31-26/h4-17,32H,1-3H3,(H,29,30,31)/b15-10+	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	5.1	37
Novartis AG US Patent					Assay Description The ER transcription assay is a reporter assay that is based on the ability of ER to induce transcription from a luciferase reporter gene containing ...				US Patent US10058534 (2018) BindingDB Entry DOI: 10.7270/Q2M32XSG
					More data for this Ligand-Target Pair