BDBM269901 (2S,3R)N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3-yl)-3-hydroxy-4,4-dimethyl-2-pentanesulfonamide or (2R,3S)N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3-yl)-3-hydroxy-4,4-dimethyl-2-pentanesulfonamide::US10058550, Example 434.0::US10058550, Example 437.0::US10221162, Example 437.0::US9845310, Example 437.0
SMILES: COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)C(C)(C)C)n1-c1c(OC)cccc1OC
InChI Key: InChIKey=ASTQDODMZCCPAQ-JLTOFOAXSA-N
Data: 6 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Apelin receptor (Homo sapiens (Human)) | BDBM269901![]() ((2S,3R)N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 120 | n/a | n/a | 7.5 | n/a |
AMGEN INC. US Patent | Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si... | US Patent US10058550 (2018) BindingDB Entry DOI: 10.7270/Q26T0PP0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM269901![]() ((2S,3R)N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 31 | n/a | n/a | 7.5 | n/a |
AMGEN INC. US Patent | Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si... | US Patent US10058550 (2018) BindingDB Entry DOI: 10.7270/Q26T0PP0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (APJ) (Homo sapiens (Human)) | BDBM269901![]() ((2S,3R)N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 31 | n/a | n/a | n/a | n/a |
AMGEN INC. US Patent | Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... | US Patent US9845310 (2017) BindingDB Entry DOI: 10.7270/Q28P62TV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM269901![]() ((2S,3R)N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 31 | n/a | n/a | n/a | n/a |
AMGEN INC. US Patent | Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... | US Patent US10221162 (2019) BindingDB Entry DOI: 10.7270/Q2ZK5JXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (APJ) (Homo sapiens (Human)) | BDBM269901![]() ((2S,3R)N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
AMGEN INC. US Patent | Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... | US Patent US9845310 (2017) BindingDB Entry DOI: 10.7270/Q28P62TV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM269901![]() ((2S,3R)N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
AMGEN INC. US Patent | Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... | US Patent US10221162 (2019) BindingDB Entry DOI: 10.7270/Q2ZK5JXS | |||||||||||
More data for this Ligand-Target Pair |