Found 8 hits for monomerid = 270203 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Apelin receptor
(Homo sapiens (Human)) | BDBM270203
((1R,2S,P)N-(4-(2,4-dimethoxy-3-pyridinyl)-5-...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(7.76,-2.26,;6.22,-2.26,;5.45,-.93,;3.91,-.93,;3.14,.41,;3.14,-2.26,;4.48,-3.03,;2.37,-3.59,;1.81,-1.49,;.48,-2.26,;.48,-3.8,;-.99,-4.27,;-1.89,-3.03,;-3.38,-2.63,;-3.78,-1.14,;-5.27,-.74,;-6.36,-1.83,;-5.96,-3.32,;-7.05,-4.41,;-8.53,-4.01,;-4.47,-3.72,;-.99,-1.78,;-1.53,.33,;-.44,1.42,;1.05,1.02,;2.14,2.11,;-.84,2.9,;-2.32,3.3,;-3.41,2.21,;-3.02,.73,;-4.1,-.36,;-5.59,.04,;6.22,.41,;7.76,.41,;8.53,1.74,;7.76,3.08,;8.53,4.41,;6.22,3.08,;5.45,1.74,)| Show InChI InChI=1S/C24H28N8O6S/c1-14-12-26-21(27-13-14)20(37-5)15(2)39(33,34)31-24-30-29-22(16-8-7-9-18(28-16)36-4)32(24)19-17(35-3)10-11-25-23(19)38-6/h7-13,15,20H,1-6H3,(H,30,31)/t15-,20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | 7.5 | n/a |
AMGEN INC.
US Patent
| Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si... |
US Patent US10058550 (2018)
BindingDB Entry DOI: 10.7270/Q26T0PP0 |
More data for this Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270203
((1R,2S,P)N-(4-(2,4-dimethoxy-3-pyridinyl)-5-...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(7.76,-2.26,;6.22,-2.26,;5.45,-.93,;3.91,-.93,;3.14,.41,;3.14,-2.26,;4.48,-3.03,;2.37,-3.59,;1.81,-1.49,;.48,-2.26,;.48,-3.8,;-.99,-4.27,;-1.89,-3.03,;-3.38,-2.63,;-3.78,-1.14,;-5.27,-.74,;-6.36,-1.83,;-5.96,-3.32,;-7.05,-4.41,;-8.53,-4.01,;-4.47,-3.72,;-.99,-1.78,;-1.53,.33,;-.44,1.42,;1.05,1.02,;2.14,2.11,;-.84,2.9,;-2.32,3.3,;-3.41,2.21,;-3.02,.73,;-4.1,-.36,;-5.59,.04,;6.22,.41,;7.76,.41,;8.53,1.74,;7.76,3.08,;8.53,4.41,;6.22,3.08,;5.45,1.74,)| Show InChI InChI=1S/C24H28N8O6S/c1-14-12-26-21(27-13-14)20(37-5)15(2)39(33,34)31-24-30-29-22(16-8-7-9-18(28-16)36-4)32(24)19-17(35-3)10-11-25-23(19)38-6/h7-13,15,20H,1-6H3,(H,30,31)/t15-,20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.0320 | n/a | n/a | 7.5 | n/a |
AMGEN INC.
US Patent
| Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si... |
US Patent US10058550 (2018)
BindingDB Entry DOI: 10.7270/Q26T0PP0 |
More data for this Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270203
((1R,2S,P)N-(4-(2,4-dimethoxy-3-pyridinyl)-5-...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(7.76,-2.26,;6.22,-2.26,;5.45,-.93,;3.91,-.93,;3.14,.41,;3.14,-2.26,;4.48,-3.03,;2.37,-3.59,;1.81,-1.49,;.48,-2.26,;.48,-3.8,;-.99,-4.27,;-1.89,-3.03,;-3.38,-2.63,;-3.78,-1.14,;-5.27,-.74,;-6.36,-1.83,;-5.96,-3.32,;-7.05,-4.41,;-8.53,-4.01,;-4.47,-3.72,;-.99,-1.78,;-1.53,.33,;-.44,1.42,;1.05,1.02,;2.14,2.11,;-.84,2.9,;-2.32,3.3,;-3.41,2.21,;-3.02,.73,;-4.1,-.36,;-5.59,.04,;6.22,.41,;7.76,.41,;8.53,1.74,;7.76,3.08,;8.53,4.41,;6.22,3.08,;5.45,1.74,)| Show InChI InChI=1S/C24H28N8O6S/c1-14-12-26-21(27-13-14)20(37-5)15(2)39(33,34)31-24-30-29-22(16-8-7-9-18(28-16)36-4)32(24)19-17(35-3)10-11-25-23(19)38-6/h7-13,15,20H,1-6H3,(H,30,31)/t15-,20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this Ligand-Target Pair | |
Apelin receptor (APJ)
(Homo sapiens (Human)) | BDBM270203
((1R,2S,P)N-(4-(2,4-dimethoxy-3-pyridinyl)-5-...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(7.76,-2.26,;6.22,-2.26,;5.45,-.93,;3.91,-.93,;3.14,.41,;3.14,-2.26,;4.48,-3.03,;2.37,-3.59,;1.81,-1.49,;.48,-2.26,;.48,-3.8,;-.99,-4.27,;-1.89,-3.03,;-3.38,-2.63,;-3.78,-1.14,;-5.27,-.74,;-6.36,-1.83,;-5.96,-3.32,;-7.05,-4.41,;-8.53,-4.01,;-4.47,-3.72,;-.99,-1.78,;-1.53,.33,;-.44,1.42,;1.05,1.02,;2.14,2.11,;-.84,2.9,;-2.32,3.3,;-3.41,2.21,;-3.02,.73,;-4.1,-.36,;-5.59,.04,;6.22,.41,;7.76,.41,;8.53,1.74,;7.76,3.08,;8.53,4.41,;6.22,3.08,;5.45,1.74,)| Show InChI InChI=1S/C24H28N8O6S/c1-14-12-26-21(27-13-14)20(37-5)15(2)39(33,34)31-24-30-29-22(16-8-7-9-18(28-16)36-4)32(24)19-17(35-3)10-11-25-23(19)38-6/h7-13,15,20H,1-6H3,(H,30,31)/t15-,20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.0320 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270203
((1R,2S,P)N-(4-(2,4-dimethoxy-3-pyridinyl)-5-...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(7.76,-2.26,;6.22,-2.26,;5.45,-.93,;3.91,-.93,;3.14,.41,;3.14,-2.26,;4.48,-3.03,;2.37,-3.59,;1.81,-1.49,;.48,-2.26,;.48,-3.8,;-.99,-4.27,;-1.89,-3.03,;-3.38,-2.63,;-3.78,-1.14,;-5.27,-.74,;-6.36,-1.83,;-5.96,-3.32,;-7.05,-4.41,;-8.53,-4.01,;-4.47,-3.72,;-.99,-1.78,;-1.53,.33,;-.44,1.42,;1.05,1.02,;2.14,2.11,;-.84,2.9,;-2.32,3.3,;-3.41,2.21,;-3.02,.73,;-4.1,-.36,;-5.59,.04,;6.22,.41,;7.76,.41,;8.53,1.74,;7.76,3.08,;8.53,4.41,;6.22,3.08,;5.45,1.74,)| Show InChI InChI=1S/C24H28N8O6S/c1-14-12-26-21(27-13-14)20(37-5)15(2)39(33,34)31-24-30-29-22(16-8-7-9-18(28-16)36-4)32(24)19-17(35-3)10-11-25-23(19)38-6/h7-13,15,20H,1-6H3,(H,30,31)/t15-,20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this Ligand-Target Pair | |
Apelin receptor (APJ)
(Homo sapiens (Human)) | BDBM270203
((1R,2S,P)N-(4-(2,4-dimethoxy-3-pyridinyl)-5-...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(7.76,-2.26,;6.22,-2.26,;5.45,-.93,;3.91,-.93,;3.14,.41,;3.14,-2.26,;4.48,-3.03,;2.37,-3.59,;1.81,-1.49,;.48,-2.26,;.48,-3.8,;-.99,-4.27,;-1.89,-3.03,;-3.38,-2.63,;-3.78,-1.14,;-5.27,-.74,;-6.36,-1.83,;-5.96,-3.32,;-7.05,-4.41,;-8.53,-4.01,;-4.47,-3.72,;-.99,-1.78,;-1.53,.33,;-.44,1.42,;1.05,1.02,;2.14,2.11,;-.84,2.9,;-2.32,3.3,;-3.41,2.21,;-3.02,.73,;-4.1,-.36,;-5.59,.04,;6.22,.41,;7.76,.41,;8.53,1.74,;7.76,3.08,;8.53,4.41,;6.22,3.08,;5.45,1.74,)| Show InChI InChI=1S/C24H28N8O6S/c1-14-12-26-21(27-13-14)20(37-5)15(2)39(33,34)31-24-30-29-22(16-8-7-9-18(28-16)36-4)32(24)19-17(35-3)10-11-25-23(19)38-6/h7-13,15,20H,1-6H3,(H,30,31)/t15-,20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this Ligand-Target Pair | |
Apelin receptor (APJ)
(Homo sapiens (Human)) | BDBM270203
((1R,2S,P)N-(4-(2,4-dimethoxy-3-pyridinyl)-5-...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(7.76,-2.26,;6.22,-2.26,;5.45,-.93,;3.91,-.93,;3.14,.41,;3.14,-2.26,;4.48,-3.03,;2.37,-3.59,;1.81,-1.49,;.48,-2.26,;.48,-3.8,;-.99,-4.27,;-1.89,-3.03,;-3.38,-2.63,;-3.78,-1.14,;-5.27,-.74,;-6.36,-1.83,;-5.96,-3.32,;-7.05,-4.41,;-8.53,-4.01,;-4.47,-3.72,;-.99,-1.78,;-1.53,.33,;-.44,1.42,;1.05,1.02,;2.14,2.11,;-.84,2.9,;-2.32,3.3,;-3.41,2.21,;-3.02,.73,;-4.1,-.36,;-5.59,.04,;6.22,.41,;7.76,.41,;8.53,1.74,;7.76,3.08,;8.53,4.41,;6.22,3.08,;5.45,1.74,)| Show InChI InChI=1S/C24H28N8O6S/c1-14-12-26-21(27-13-14)20(37-5)15(2)39(33,34)31-24-30-29-22(16-8-7-9-18(28-16)36-4)32(24)19-17(35-3)10-11-25-23(19)38-6/h7-13,15,20H,1-6H3,(H,30,31)/t15-,20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270203
((1R,2S,P)N-(4-(2,4-dimethoxy-3-pyridinyl)-5-...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(7.76,-2.26,;6.22,-2.26,;5.45,-.93,;3.91,-.93,;3.14,.41,;3.14,-2.26,;4.48,-3.03,;2.37,-3.59,;1.81,-1.49,;.48,-2.26,;.48,-3.8,;-.99,-4.27,;-1.89,-3.03,;-3.38,-2.63,;-3.78,-1.14,;-5.27,-.74,;-6.36,-1.83,;-5.96,-3.32,;-7.05,-4.41,;-8.53,-4.01,;-4.47,-3.72,;-.99,-1.78,;-1.53,.33,;-.44,1.42,;1.05,1.02,;2.14,2.11,;-.84,2.9,;-2.32,3.3,;-3.41,2.21,;-3.02,.73,;-4.1,-.36,;-5.59,.04,;6.22,.41,;7.76,.41,;8.53,1.74,;7.76,3.08,;8.53,4.41,;6.22,3.08,;5.45,1.74,)| Show InChI InChI=1S/C24H28N8O6S/c1-14-12-26-21(27-13-14)20(37-5)15(2)39(33,34)31-24-30-29-22(16-8-7-9-18(28-16)36-4)32(24)19-17(35-3)10-11-25-23(19)38-6/h7-13,15,20H,1-6H3,(H,30,31)/t15-,20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.0320 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this Ligand-Target Pair | |