null

SMILES: CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1nc(N)ncc1Br

InChI Key: InChIKey=QNGSVLFIAPLXJA-MGCOHNPYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 270861   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM270861 (US10059709, 7) Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1nc(N)ncc1Br |r,wU:9.12,wD:6.5,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;-.67,3.57,;-2,2.8,;-2,1.26,;-.67,.49,;.67,1.26,;-3.33,.49,;-4.67,1.26,;-3.33,-1.05,;-2,-1.82,;-2,-3.36,;-.67,-4.13,;-3.33,-4.13,;-4.67,-3.36,;-4.67,-1.82,;-6,-1.05,)| Show InChI InChI=1S/C13H22BrN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-11(14)7-17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Elanco Tiergesundheit AG US Patent					Assay Description All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...				US Patent US10059709 (2018) BindingDB Entry DOI: 10.7270/Q25X2BZX
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM270861 (US10059709, 7) Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1nc(N)ncc1Br |r,wU:9.12,wD:6.5,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;-.67,3.57,;-2,2.8,;-2,1.26,;-.67,.49,;.67,1.26,;-3.33,.49,;-4.67,1.26,;-3.33,-1.05,;-2,-1.82,;-2,-3.36,;-.67,-4.13,;-3.33,-4.13,;-4.67,-3.36,;-4.67,-1.82,;-6,-1.05,)| Show InChI InChI=1S/C13H22BrN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-11(14)7-17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10-	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Elanco Tiergesundheit AG US Patent					Assay Description All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...				US Patent US10059709 (2018) BindingDB Entry DOI: 10.7270/Q25X2BZX
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM270861 (US10059709, 7) Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1nc(N)ncc1Br |r,wU:9.12,wD:6.5,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;-.67,3.57,;-2,2.8,;-2,1.26,;-.67,.49,;.67,1.26,;-3.33,.49,;-4.67,1.26,;-3.33,-1.05,;-2,-1.82,;-2,-3.36,;-.67,-4.13,;-3.33,-4.13,;-4.67,-3.36,;-4.67,-1.82,;-6,-1.05,)| Show InChI InChI=1S/C13H22BrN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-11(14)7-17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Elanco Tiergesundheit AG US Patent					Assay Description All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...				US Patent US10059709 (2018) BindingDB Entry DOI: 10.7270/Q25X2BZX
					More data for this Ligand-Target Pair