BDBM270874 US10059709, 20

SMILES: CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1c(cnc2sccc12)C#N

InChI Key: InChIKey=CLLNFELNPVGVDT-AULYBMBSSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 270874   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM270874 (US10059709, 20) Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1c(cnc2sccc12)C#N |r,wU:6.5,wD:9.12,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;.67,1.26,;-.67,.49,;-2,1.26,;-2,2.8,;-.67,3.57,;-3.33,.49,;-3.33,-1.05,;-4.67,-1.82,;-4.67,-3.36,;-3.33,-4.13,;-2,-3.36,;-.54,-3.84,;.37,-2.59,;-.54,-1.35,;-2,-1.82,;-6,-1.05,;-6,.49,)| Show InChI InChI=1S/C16H19N3O3S2/c1-18-24(20,21)10-11-2-4-13(5-3-11)22-15-12(8-17)9-19-16-14(15)6-7-23-16/h6-7,9,11,13,18H,2-5,10H2,1H3/t11-,13-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Elanco Tiergesundheit AG US Patent					Assay Description All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...				US Patent US10059709 (2018) BindingDB Entry DOI: 10.7270/Q25X2BZX
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM270874 (US10059709, 20) Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1c(cnc2sccc12)C#N |r,wU:6.5,wD:9.12,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;.67,1.26,;-.67,.49,;-2,1.26,;-2,2.8,;-.67,3.57,;-3.33,.49,;-3.33,-1.05,;-4.67,-1.82,;-4.67,-3.36,;-3.33,-4.13,;-2,-3.36,;-.54,-3.84,;.37,-2.59,;-.54,-1.35,;-2,-1.82,;-6,-1.05,;-6,.49,)| Show InChI InChI=1S/C16H19N3O3S2/c1-18-24(20,21)10-11-2-4-13(5-3-11)22-15-12(8-17)9-19-16-14(15)6-7-23-16/h6-7,9,11,13,18H,2-5,10H2,1H3/t11-,13-	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Elanco Tiergesundheit AG US Patent					Assay Description All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...				US Patent US10059709 (2018) BindingDB Entry DOI: 10.7270/Q25X2BZX
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM270874 (US10059709, 20) Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1c(cnc2sccc12)C#N |r,wU:6.5,wD:9.12,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;.67,1.26,;-.67,.49,;-2,1.26,;-2,2.8,;-.67,3.57,;-3.33,.49,;-3.33,-1.05,;-4.67,-1.82,;-4.67,-3.36,;-3.33,-4.13,;-2,-3.36,;-.54,-3.84,;.37,-2.59,;-.54,-1.35,;-2,-1.82,;-6,-1.05,;-6,.49,)| Show InChI InChI=1S/C16H19N3O3S2/c1-18-24(20,21)10-11-2-4-13(5-3-11)22-15-12(8-17)9-19-16-14(15)6-7-23-16/h6-7,9,11,13,18H,2-5,10H2,1H3/t11-,13-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Elanco Tiergesundheit AG US Patent					Assay Description All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...				US Patent US10059709 (2018) BindingDB Entry DOI: 10.7270/Q25X2BZX
					More data for this Ligand-Target Pair