BDBM272547 3-(2-methylpyridin-4-yl)-5,6-dihydro-1H-pyrazolo[4,3-g]quinazolin-7(8H)-one::US10065967, Example 13::US10759805, Ex 13::US9745307, Example 13

SMILES: Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)NCc3cc12

InChI Key: InChIKey=FEIJZJGMKBIZGG-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 272547   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM272547 (3-(2-methylpyridin-4-yl)-5,6-dihydro-1H-pyrazolo[4...) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)NCc3cc12 Show InChI InChI=1S/C15H13N5O/c1-8-4-9(2-3-16-8)14-11-5-10-7-17-15(21)18-12(10)6-13(11)19-20-14/h2-6H,7H2,1H3,(H,19,20)(H2,17,18,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Merck, Sharp & Dohme Corp. US Patent					Assay Description Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...				US Patent US10065967 (2018) BindingDB Entry DOI: 10.7270/Q2CF9S47
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM272547 (3-(2-methylpyridin-4-yl)-5,6-dihydro-1H-pyrazolo[4...) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)NCc3cc12 Show InChI InChI=1S/C15H13N5O/c1-8-4-9(2-3-16-8)14-11-5-10-7-17-15(21)18-12(10)6-13(11)19-20-14/h2-6H,7H2,1H3,(H,19,20)(H2,17,18,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Human: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound w...				US Patent US10759805 (2020)
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM272547 (3-(2-methylpyridin-4-yl)-5,6-dihydro-1H-pyrazolo[4...) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)NCc3cc12 Show InChI InChI=1S/C15H13N5O/c1-8-4-9(2-3-16-8)14-11-5-10-7-17-15(21)18-12(10)6-13(11)19-20-14/h2-6H,7H2,1H3,(H,19,20)(H2,17,18,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...				US Patent US9745307 (2017) BindingDB Entry DOI: 10.7270/Q28G8NTK
					More data for this Ligand-Target Pair