BDBM273230 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridine dihydrochloride::US10071079, Example 4::US10478424, Example 4
SMILES: CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cn2ncnc2c(C)c1C
InChI Key: InChIKey=VUZNXUYFHHEUMC-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM273230 (6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | 25 |
Bristol-Myers Squibb Company US Patent | Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... | US Patent US10071079 (2018) BindingDB Entry DOI: 10.7270/Q2VD71GV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM273230 (6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | 25 |
Bristol-Myers Squibb Company US Patent | Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... | US Patent US10071079 (2018) BindingDB Entry DOI: 10.7270/Q2VD71GV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 9 (Homo sapiens (Human)) | BDBM273230 (6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... | US Patent US10478424 (2019) BindingDB Entry DOI: 10.7270/Q2QZ2DB0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM273230 (6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... | US Patent US10478424 (2019) BindingDB Entry DOI: 10.7270/Q2QZ2DB0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM273230 (6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... | US Patent US10478424 (2019) BindingDB Entry DOI: 10.7270/Q2QZ2DB0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 9 (Homo sapiens (Human)) | BDBM273230 (6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.59E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Bristol-Myers Squibb Company US Patent | Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... | US Patent US10071079 (2018) BindingDB Entry DOI: 10.7270/Q2VD71GV | |||||||||||
More data for this Ligand-Target Pair |