BDBM274502 N-(6-(1-(1-(1H-imidazole-4- carbonyl)piperidin-4-yl)-4-(4- fluorophenyl)-1H-imidazol-5- yl)imidazo(1,2-b]pyridazin-2-yl)-2- fluoroisonicotinamide::US9556179, Compound 72

SMILES: Fc1ccc(cc1)-c1ncn(C2CCN(CC2)C(=O)c2c[nH]cn2)c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1

InChI Key: InChIKey=XBSLPIZNQSAFOH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274502   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Casein kinase I isoform delta (Homo sapiens (Human))	BDBM274502 (N-(6-(1-(1-(1H-imidazole-4- carbonyl)piperidin-4-y...) Show SMILES Fc1ccc(cc1)-c1ncn(C2CCN(CC2)C(=O)c2c[nH]cn2)c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1 Show InChI InChI=1S/C30H24F2N10O2/c31-20-3-1-18(2-4-20)27-28(41(17-36-27)21-8-11-40(12-9-21)30(44)23-14-33-16-35-23)22-5-6-26-37-25(15-42(26)39-22)38-29(43)19-7-10-34-24(32)13-19/h1-7,10,13-17,21H,8-9,11-12H2,(H,33,35)(H,38,43)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.183	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair
Casein kinase I isoform epsilon (Homo sapiens (Human))	BDBM274502 (N-(6-(1-(1-(1H-imidazole-4- carbonyl)piperidin-4-y...) Show SMILES Fc1ccc(cc1)-c1ncn(C2CCN(CC2)C(=O)c2c[nH]cn2)c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1 Show InChI InChI=1S/C30H24F2N10O2/c31-20-3-1-18(2-4-20)27-28(41(17-36-27)21-8-11-40(12-9-21)30(44)23-14-33-16-35-23)22-5-6-26-37-25(15-42(26)39-22)38-29(43)19-7-10-34-24(32)13-19/h1-7,10,13-17,21H,8-9,11-12H2,(H,33,35)(H,38,43)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.559	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair