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SMILES: c1cc2cc(ncc2[nH]1)-n1ccc2ccncc12

InChI Key: InChIKey=VRZMDJVXNAXIHW-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281557   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Microtubule-associated protein tau


(Homo sapiens (Human))		BDBM281557
PNG
(US10022461, Compound 8)
Show SMILES c1cc2cc(ncc2[nH]1)-n1ccc2ccncc12
Show InChI InChI=1S/C14H10N4/c1-4-15-9-13-10(1)3-6-18(13)14-7-11-2-5-16-12(11)8-17-14/h1-9,16H
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PC cid
PC sid
UniChem
US Patent
 0.480 -12.7n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...

US Patent US10022461 (2018)


BindingDB Entry DOI: 10.7270/Q2959KK6
More data for this
Ligand-Target Pair