BDBM282930 6-(4-(4-fluorophenyl)-1-isopropyl-1H-imidazol-5- yl)imidazo[1,2-b]pyridazine-3-carboxamide::US10287295, Example 135'::US9884868, Example 135'

SMILES: CC(C)n1cnc(c1-c1ccc2ncc(C(N)=O)n2n1)-c1ccc(F)cc1

InChI Key: InChIKey=VVWPOXCVDNYFIL-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 282930   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM282930 (6-(4-(4-fluorophenyl)-1-isopropyl-1H-imidazol-5- y...) Show SMILES CC(C)n1cnc(c1-c1ccc2ncc(C(N)=O)n2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C19H17FN6O/c1-11(2)25-10-23-17(12-3-5-13(20)6-4-12)18(25)14-7-8-16-22-9-15(19(21)27)26(16)24-14/h3-11H,1-2H3,(H2,21,27)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type II (Homo sapiens (Human))	BDBM282930 (6-(4-(4-fluorophenyl)-1-isopropyl-1H-imidazol-5- y...) Show SMILES CC(C)n1cnc(c1-c1ccc2ncc(C(N)=O)n2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C19H17FN6O/c1-11(2)25-10-23-17(12-3-5-13(20)6-4-12)18(25)14-7-8-16-22-9-15(19(21)27)26(16)24-14/h3-11H,1-2H3,(H2,21,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q2B85BFB
					More data for this Ligand-Target Pair
TGF-betaR1 T204D (Homo sapiens (Human))	BDBM282930 (6-(4-(4-fluorophenyl)-1-isopropyl-1H-imidazol-5- y...) Show SMILES CC(C)n1cnc(c1-c1ccc2ncc(C(N)=O)n2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C19H17FN6O/c1-11(2)25-10-23-17(12-3-5-13(20)6-4-12)18(25)14-7-8-16-22-9-15(19(21)27)26(16)24-14/h3-11H,1-2H3,(H2,21,27)	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q2B85BFB
					More data for this Ligand-Target Pair
TGF-beta receptor type II (Homo sapiens (Human))	BDBM282930 (6-(4-(4-fluorophenyl)-1-isopropyl-1H-imidazol-5- y...) Show SMILES CC(C)n1cnc(c1-c1ccc2ncc(C(N)=O)n2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C19H17FN6O/c1-11(2)25-10-23-17(12-3-5-13(20)6-4-12)18(25)14-7-8-16-22-9-15(19(21)27)26(16)24-14/h3-11H,1-2H3,(H2,21,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent									US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair