BDBM283034 6-(4-(5-chloro-2,4-difluorophenyl)-1-(2,2- difluoroethyl)-1H-imidazol-5-yl)imidazo[1,2- a]pyridine-3-carboxamide::US10287295, Example 235'::US9884868, Example 235'

SMILES: NC(=O)c1cnc2ccc(cn12)-c1c(ncn1CC(F)F)-c1cc(Cl)c(F)cc1F

InChI Key: InChIKey=DVVZKICZALNZIH-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 283034   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283034 (6-(4-(5-chloro-2,4-difluorophenyl)-1-(2,2- difluor...) Show SMILES NC(=O)c1cnc2ccc(cn12)-c1c(ncn1CC(F)F)-c1cc(Cl)c(F)cc1F Show InChI InChI=1S/C19H12ClF4N5O/c20-11-3-10(12(21)4-13(11)22)17-18(28(8-27-17)7-15(23)24)9-1-2-16-26-5-14(19(25)30)29(16)6-9/h1-6,8,15H,7H2,(H2,25,30)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type II (Homo sapiens (Human))	BDBM283034 (6-(4-(5-chloro-2,4-difluorophenyl)-1-(2,2- difluor...) Show SMILES NC(=O)c1cnc2ccc(cn12)-c1c(ncn1CC(F)F)-c1cc(Cl)c(F)cc1F Show InChI InChI=1S/C19H12ClF4N5O/c20-11-3-10(12(21)4-13(11)22)17-18(28(8-27-17)7-15(23)24)9-1-2-16-26-5-14(19(25)30)29(16)6-9/h1-6,8,15H,7H2,(H2,25,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q2B85BFB
					More data for this Ligand-Target Pair
TGF-betaR1 T204D (Homo sapiens (Human))	BDBM283034 (6-(4-(5-chloro-2,4-difluorophenyl)-1-(2,2- difluor...) Show SMILES NC(=O)c1cnc2ccc(cn12)-c1c(ncn1CC(F)F)-c1cc(Cl)c(F)cc1F Show InChI InChI=1S/C19H12ClF4N5O/c20-11-3-10(12(21)4-13(11)22)17-18(28(8-27-17)7-15(23)24)9-1-2-16-26-5-14(19(25)30)29(16)6-9/h1-6,8,15H,7H2,(H2,25,30)	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q2B85BFB
					More data for this Ligand-Target Pair
TGF-beta receptor type II (Homo sapiens (Human))	BDBM283034 (6-(4-(5-chloro-2,4-difluorophenyl)-1-(2,2- difluor...) Show SMILES NC(=O)c1cnc2ccc(cn12)-c1c(ncn1CC(F)F)-c1cc(Cl)c(F)cc1F Show InChI InChI=1S/C19H12ClF4N5O/c20-11-3-10(12(21)4-13(11)22)17-18(28(8-27-17)7-15(23)24)9-1-2-16-26-5-14(19(25)30)29(16)6-9/h1-6,8,15H,7H2,(H2,25,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent									US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair