BDBM283229 4'-(5-Aminopyrazin-2-yl)-3'-fluoro-N-(3- hydroxy-1,1-dimethylpropyl)biphenyl-2- sulfonamide::US9745328, Compound 102::US9884878, Compound 102
SMILES: CC(C)(CCO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1
InChI Key: InChIKey=SECHLWOSZHEETL-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-lipoxygenase/FLAP (Homo sapiens (Human)) | BDBM283229 (4'-(5-Aminopyrazin-2-yl)-3'-fluoro-N-(3- hydroxy-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... | US Patent US9884878 (2018) BindingDB Entry DOI: 10.7270/Q2R78H8P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Flap endonuclease 1 (Homo sapiens (Human)) | BDBM283229 (4'-(5-Aminopyrazin-2-yl)-3'-fluoro-N-(3- hydroxy-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma... | US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446 | |||||||||||
More data for this Ligand-Target Pair |