BDBM285797 US10080744, Example 11/8

SMILES: CC[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2CC(C)(C)OC)-c2noc(CC(C)(C)OC=O)n2)c(Cl)c1Cl)C(F)(F)F

InChI Key: InChIKey=ZFPXGNBLAZJWDM-INIZCTEOSA-N

Data: 1 IC50  1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 285797   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM285797 (US10080744, Example 11/8) Show SMILES CC[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2CC(C)(C)OC)-c2noc(CC(C)(C)OC=O)n2)c(Cl)c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C25H29Cl2F3N4O6S2/c1-7-16(25(28,29)30)34-42(36,37)15-9-8-13(18(26)19(15)27)20-14(10-23(2,3)38-6)31-22(41-20)21-32-17(40-33-21)11-24(4,5)39-12-35/h8-9,12,16,34H,7,10-11H2,1-6H3/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...				US Patent US10080744 (2018) BindingDB Entry DOI: 10.7270/Q21J9CVM
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM285797 (US10080744, Example 11/8) Show SMILES CC[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2CC(C)(C)OC)-c2noc(CC(C)(C)OC=O)n2)c(Cl)c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C25H29Cl2F3N4O6S2/c1-7-16(25(28,29)30)34-42(36,37)15-9-8-13(18(26)19(15)27)20-14(10-23(2,3)38-6)31-22(41-20)21-32-17(40-33-21)11-24(4,5)39-12-35/h8-9,12,16,34H,7,10-11H2,1-6H3/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.350	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description For the RORγt construct used in the ThermoFluor assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR&...				US Patent US10080744 (2018) BindingDB Entry DOI: 10.7270/Q21J9CVM
					More data for this Ligand-Target Pair