null

SMILES: CC[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2CN2CC(F)(F)C[C@@H]2C)-c2noc(CC(C)(C)C(O)=O)n2)c(C(F)F)c1F)C(F)(F)F

InChI Key: InChIKey=VSKATRWUJUSISW-LRDDRELGSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 285804   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM285804 (US10080744, Example 12/3) Show SMILES CC[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2CN2CC(F)(F)C[C@@H]2C)-c2noc(CC(C)(C)C(O)=O)n2)c(C(F)F)c1F)C(F)(F)F |r| Show InChI InChI=1S/C27H29F8N5O5S2/c1-5-16(27(33,34)35)39-47(43,44)15-7-6-13(18(19(15)28)21(29)30)20-14(10-40-11-26(31,32)8-12(40)2)36-23(46-20)22-37-17(45-38-22)9-25(3,4)24(41)42/h6-7,12,16,21,39H,5,8-11H2,1-4H3,(H,41,42)/t12-,16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...				US Patent US10080744 (2018) BindingDB Entry DOI: 10.7270/Q21J9CVM
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM285804 (US10080744, Example 12/3) Show SMILES CC[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2CN2CC(F)(F)C[C@@H]2C)-c2noc(CC(C)(C)C(O)=O)n2)c(C(F)F)c1F)C(F)(F)F |r| Show InChI InChI=1S/C27H29F8N5O5S2/c1-5-16(27(33,34)35)39-47(43,44)15-7-6-13(18(19(15)28)21(29)30)20-14(10-40-11-26(31,32)8-12(40)2)36-23(46-20)22-37-17(45-38-22)9-25(3,4)24(41)42/h6-7,12,16,21,39H,5,8-11H2,1-4H3,(H,41,42)/t12-,16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.0630	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description For the RORγt construct used in the ThermoFluor assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR&...				US Patent US10080744 (2018) BindingDB Entry DOI: 10.7270/Q21J9CVM
					More data for this Ligand-Target Pair