BindingDB logo
myBDB logout

BDBM288249 5-(2-Cyclopropyl-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-7-yl)-7-::US10087185, Example 67

SMILES: Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2cc(nn12)C1CC1)C(F)(F)F

InChI Key: InChIKey=VCKRMUILLPQZCR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288249   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288249
PNG
(5-(2-Cyclopropyl-6-(trifluoromethyl)pyrazolo[1,5-a...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2cc(nn12)C1CC1)C(F)(F)F
Show InChI InChI=1S/C20H16F3N3O/c1-10-6-13(7-12-8-17(27)24-18(10)12)19-15(20(21,22)23)5-4-14-9-16(11-2-3-11)25-26(14)19/h4-7,9,11H,2-3,8H2,1H3,(H,24,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0500n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)


BindingDB Entry DOI: 10.7270/Q2QZ2D0H
More data for this
Ligand-Target Pair