BDBM289896 1-(1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin- 2-yloxy]-naphthalen-2-ylmethyl}- piperidin-4-yl)-pyrrolidin-2-one::US9573957, Example 36
SMILES: O=C1CCCN1C1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1
InChI Key: InChIKey=OHFYIRPFFNEYAP-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Leukotriene A4 hydrolase (Homo sapiens (Human)) | BDBM289896 (1-(1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin- 2-yloxy]-n...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ... | US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT | |||||||||||
More data for this Ligand-Target Pair |