null

SMILES: O=C(C1CCc2cc(ccc12)-n1cnnn1)N1CCN2C[C@H](OC[C@@H]2C1)c1ccc2C(=O)OCCc2c1

InChI Key: InChIKey=GWYZUXZJVMGYTN-BIYQJSDESA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 290037   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM290037 (US9573961, Example 22 | US9573961, Example 86 | US...) Show SMILES O=C(C1CCc2cc(ccc12)-n1cnnn1)N1CCN2C[C@H](OC[C@@H]2C1)c1ccc2C(=O)OCCc2c1 |r| Show InChI InChI=1S/C27H28N6O4/c34-26(24-5-1-17-12-20(3-6-22(17)24)33-16-28-29-30-33)32-9-8-31-14-25(37-15-21(31)13-32)19-2-4-23-18(11-19)7-10-36-27(23)35/h2-4,6,11-12,16,21,24-25H,1,5,7-10,13-15H2/t21-,24?,25-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	140	n/a	n/a	n/a	n/a	7.4	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...				US Patent US9573961 (2017) BindingDB Entry DOI: 10.7270/Q241704N
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM290037 (US9573961, Example 22 | US9573961, Example 86 | US...) Show SMILES O=C(C1CCc2cc(ccc12)-n1cnnn1)N1CCN2C[C@H](OC[C@@H]2C1)c1ccc2C(=O)OCCc2c1 |r| Show InChI InChI=1S/C27H28N6O4/c34-26(24-5-1-17-12-20(3-6-22(17)24)33-16-28-29-30-33)32-9-8-31-14-25(37-15-21(31)13-32)19-2-4-23-18(11-19)7-10-36-27(23)35/h2-4,6,11-12,16,21,24-25H,1,5,7-10,13-15H2/t21-,24?,25-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	80	n/a	n/a	n/a	n/a	7.4	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...				US Patent US9573961 (2017) BindingDB Entry DOI: 10.7270/Q241704N
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM290037 (US9573961, Example 22 | US9573961, Example 86 | US...) Show SMILES O=C(C1CCc2cc(ccc12)-n1cnnn1)N1CCN2C[C@H](OC[C@@H]2C1)c1ccc2C(=O)OCCc2c1 |r| Show InChI InChI=1S/C27H28N6O4/c34-26(24-5-1-17-12-20(3-6-22(17)24)33-16-28-29-30-33)32-9-8-31-14-25(37-15-21(31)13-32)19-2-4-23-18(11-19)7-10-36-27(23)35/h2-4,6,11-12,16,21,24-25H,1,5,7-10,13-15H2/t21-,24?,25-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	90	n/a	n/a	n/a	n/a	7.4	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...				US Patent US9573961 (2017) BindingDB Entry DOI: 10.7270/Q241704N
					More data for this Ligand-Target Pair