BDBM29508 Frenolicin B
SMILES: CCC[C@H]1O[C@@H]2CC(=O)O[C@@H]2C2=C1C(=O)c1c(O)cccc1C2=O
InChI Key: InChIKey=AVCPRTNVVRPELB-YRUZYCQGSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM29508 (Frenolicin B) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 198 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Wyeth Research | Assay Description AKT1 was assayed using constitutively active Myr-AKT1 in low-binding 96-well plates. The kinase reactions were initiated by the addition of assay mix... | J Med Chem 52: 2181-4 (2009) Article DOI: 10.1021/jm900075g BindingDB Entry DOI: 10.7270/Q2V69GW9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM29508 (Frenolicin B) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 313 | n/a | n/a | n/a | n/a | n/a | n/a |
Covalution Pharma BV Curated by ChEMBL | Assay Description Inhibition of human AKT1 using biotinylated GSKalpha peptide (SGRARTSSFA) as a substrate after 1 hr | J Med Chem 55: 6243-62 (2012) Article DOI: 10.1021/jm3003203 BindingDB Entry DOI: 10.7270/Q2X92CGP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM29508 (Frenolicin B) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 198 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of AKT1 (unknown origin) by high-throughput screen assay | Bioorg Med Chem Lett 24: 271-4 (2013) Article DOI: 10.1016/j.bmcl.2013.11.020 BindingDB Entry DOI: 10.7270/Q25T3MZK | |||||||||||
More data for this Ligand-Target Pair |