BDBM296084 2-(2-benzyl-2H-indazol-6-yloxy)- pyrido[3,4-d]pyrimidin-4-ol::US10112940, Example 12::US10202381, Example 12::US10208039, Example 12::US10611763, Example 12::US10815234, Example 12

SMILES: Oc1nc(Oc2ccc3cn(Cc4ccccc4)nc3c2)nc2cnccc12

InChI Key: InChIKey=BBDTWEHTHUQEHL-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 296084   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM296084 (2-(2-benzyl-2H-indazol-6-yloxy)- pyrido[3,4-d]pyri...) Show SMILES Oc1nc(Oc2ccc3cn(Cc4ccccc4)nc3c2)nc2cnccc12 Show InChI InChI=1S/C21H15N5O2/c27-20-17-8-9-22-11-19(17)23-21(24-20)28-16-7-6-15-13-26(25-18(15)10-16)12-14-4-2-1-3-5-14/h1-11,13H,12H2,(H,23,24,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	25
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10112940 (2018) BindingDB Entry DOI: 10.7270/Q2X0692W
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM296084 (2-(2-benzyl-2H-indazol-6-yloxy)- pyrido[3,4-d]pyri...) Show SMILES Oc1nc(Oc2ccc3cn(Cc4ccccc4)nc3c2)nc2cnccc12 Show InChI InChI=1S/C21H15N5O2/c27-20-17-8-9-22-11-19(17)23-21(24-20)28-16-7-6-15-13-26(25-18(15)10-16)12-14-4-2-1-3-5-14/h1-11,13H,12H2,(H,23,24,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...				US Patent US10202381 (2019) BindingDB Entry DOI: 10.7270/Q2SX6GBM
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)(2-372) (Homo sapiens (Human))	BDBM296084 (2-(2-benzyl-2H-indazol-6-yloxy)- pyrido[3,4-d]pyri...) Show SMILES Oc1nc(Oc2ccc3cn(Cc4ccccc4)nc3c2)nc2cnccc12 Show InChI InChI=1S/C21H15N5O2/c27-20-17-8-9-22-11-19(17)23-21(24-20)28-16-7-6-15-13-26(25-18(15)10-16)12-14-4-2-1-3-5-14/h1-11,13H,12H2,(H,23,24,27)	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10815234 (2020)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM296084 (2-(2-benzyl-2H-indazol-6-yloxy)- pyrido[3,4-d]pyri...) Show SMILES Oc1nc(Oc2ccc3cn(Cc4ccccc4)nc3c2)nc2cnccc12 Show InChI InChI=1S/C21H15N5O2/c27-20-17-8-9-22-11-19(17)23-21(24-20)28-16-7-6-15-13-26(25-18(15)10-16)12-14-4-2-1-3-5-14/h1-11,13H,12H2,(H,23,24,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10611763 (2020)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM296084 (2-(2-benzyl-2H-indazol-6-yloxy)- pyrido[3,4-d]pyri...) Show SMILES Oc1nc(Oc2ccc3cn(Cc4ccccc4)nc3c2)nc2cnccc12 Show InChI InChI=1S/C21H15N5O2/c27-20-17-8-9-22-11-19(17)23-21(24-20)28-16-7-6-15-13-26(25-18(15)10-16)12-14-4-2-1-3-5-14/h1-11,13H,12H2,(H,23,24,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...				US Patent US10208039 (2019) BindingDB Entry DOI: 10.7270/Q241706J
					More data for this Ligand-Target Pair