BDBM297408 3-Amino-6-(4-fluoro-phenyl)-5-trifluoromethyl-pyridine-2-carboxylic acid ((R)-3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide::US10117858, Example 8

SMILES: C[C@@](O)(CNC(=O)c1nc(-c2ccc(F)cc2)c(cc1N)C(F)(F)F)C(F)(F)F

InChI Key: InChIKey=TZBFDPNSDFVMAL-OAHLLOKOSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 297408   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM297408 (3-Amino-6-(4-fluoro-phenyl)-5-trifluoromethyl-pyri...) Show SMILES C[C@@](O)(CNC(=O)c1nc(-c2ccc(F)cc2)c(cc1N)C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C17H14F7N3O2/c1-15(29,17(22,23)24)7-26-14(28)13-11(25)6-10(16(19,20)21)12(27-13)8-2-4-9(18)5-3-8/h2-6,29H,7,25H2,1H3,(H,26,28)/t15-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...				US Patent US10117858 (2018) BindingDB Entry DOI: 10.7270/Q2W0980D
					More data for this Ligand-Target Pair