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BDBM299670 US9593110, Example 45

SMILES: CB(O)NC(C)(C)C(=O)NC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ncc(C)o1)C(O)=O

InChI Key: InChIKey=TYSHHEQIVYCAQG-PZJWPPBQSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 299670   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM299670
PNG
(US9593110, Example 45)
Show SMILES CB(O)NC(C)(C)C(=O)NC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ncc(C)o1)C(O)=O |r|
Show InChI InChI=1S/C28H33BClFN4O6/c1-16-14-32-25(41-16)24(36)34-21(12-19(26(37)38)15-33-27(39)28(2,3)35-29(4)40)11-17-5-7-18(8-6-17)22-13-20(30)9-10-23(22)31/h5-10,13-14,19,21,35,40H,11-12,15H2,1-4H3,(H,33,39)(H,34,36)(H,37,38)/t19-,21+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

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PC cid
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US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair