BDBM300087 N-[(1R,2R)-2- hydroxy- cyclobutyl]- 6-[4-(4-methoxy- 1H-pyrazolo[3,4- b]pyridin-3- yl)piperidin-1-yl]-2- [(2R)- tetrahydrofuran-2- ylmethoxy] pyrimidine- 4-carboxamide::US9593097, Example 467
SMILES: COc1ccnc2[nH]nc(C3CCN(CC3)c3cc(nc(OC[C@H]4CCCO4)n3)C(=O)N[C@@H]3CC[C@H]3O)c12
InChI Key:
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human)) | BDBM300087 (N-[(1R,2R)-2- hydroxy- cyclobutyl]- 6-[4-(4-methox...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility... | US Patent US9593097 (2017) BindingDB Entry DOI: 10.7270/Q2GM89BD | |||||||||||
More data for this Ligand-Target Pair |