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BDBM300276 US9593110, 18-10

SMILES: N[C@@H](C[C@@H](Cc1ccc(cc1Cl)-c1cc(Cl)ccc1F)NC(=O)c1cc(on1)C1CC1)C(O)=O

InChI Key: InChIKey=ZJPRRURMDRRMKB-UZLBHIALSA-N

Data: 1 KI

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300276   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM300276
PNG
(US9593110, 18-10)
Show SMILES N[C@@H](C[C@@H](Cc1ccc(cc1Cl)-c1cc(Cl)ccc1F)NC(=O)c1cc(on1)C1CC1)C(O)=O
Show InChI InChI=1S/C24H22Cl2FN3O4/c25-15-5-6-19(27)17(9-15)13-3-4-14(18(26)8-13)7-16(10-20(28)24(32)33)29-23(31)21-11-22(34-30-21)12-1-2-12/h3-6,8-9,11-12,16,20H,1-2,7,10,28H2,(H,29,31)(H,32,33)/t16-,20+/m1/s1
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KEGG

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PC cid
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US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair