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SMILES: NC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1coc(n1)C1CC1)C(O)=O

InChI Key: InChIKey=CBTVGQLBGPMHJP-PKOBYXMFSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300285   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM300285
PNG
(US9593110, 21-2)
Show SMILES NC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1coc(n1)C1CC1)C(O)=O
Show InChI InChI=1S/C25H25ClFN3O4/c26-18-7-8-21(27)20(11-18)15-3-1-14(2-4-15)9-19(10-17(12-28)25(32)33)29-23(31)22-13-34-24(30-22)16-5-6-16/h1-4,7-8,11,13,16-17,19H,5-6,9-10,12,28H2,(H,29,31)(H,32,33)/t17-,19+/m0/s1
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KEGG

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PC cid
PC sid
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US Patent
 2.20n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair