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BDBM300712 US10130642, Example 4-8

SMILES: OCC(CC(Cc1ccc(cc1)-c1ccccc1F)NC(=O)c1cn(O)nn1)C(O)=O

InChI Key: InChIKey=SIYGAEYCKFDCJW-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300712   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM300712
PNG
(US10130642, Example 4-8)
Show SMILES OCC(CC(Cc1ccc(cc1)-c1ccccc1F)NC(=O)c1cn(O)nn1)C(O)=O
Show InChI InChI=1S/C21H21FN4O5/c22-18-4-2-1-3-17(18)14-7-5-13(6-8-14)9-16(10-15(12-27)21(29)30)23-20(28)19-11-26(31)25-24-19/h1-8,11,15-16,27,31H,9-10,12H2,(H,23,28)(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US10130642 (2018)


BindingDB Entry DOI: 10.7270/Q29Z96ZH
More data for this
Ligand-Target Pair