BDBM301426 4-amino-7-{1-[1-(3,4-difluorophenyl)-1H-1,2,3-triazol-4-yl]propyl}-5-[2-(trifluoromethyl)pyrimidin-5-yl]pyrrolo[2,1-f][1,2,4]triazine-6-carbonitrile,enantiomer 2::US10131670, Example 9
SMILES: CCC(c1cn(nn1)-c1ccc(F)c(F)c1)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12
InChI Key: InChIKey=WWOJLYKLBDUQQC-UHFFFAOYSA-N
Data: 2 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301426 (4-amino-7-{1-[1-(3,4-difluorophenyl)-1H-1,2,3-tria...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 41.2 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301426 (4-amino-7-{1-[1-(3,4-difluorophenyl)-1H-1,2,3-tria...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 28.4 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair |