BDBM304182 (R)-4-[(2-{5-[3-chloro-6-(difluoromethoxy)-2-fluorophenyl]-1-oxidopyridin-2-yl}-3-cyclopropylpropanoyl)amino]-2-fluorobenzoic Acid::US10143681, Example 73

SMILES: OC(=O)c1ccc(NC(=O)[C@H](CC2CC2)c2ccc(c[n+]2[O-])-c2c(F)c(Cl)ccc2OC(F)F)cc1F

InChI Key: InChIKey=LRECJFITXRQCOV-MRXNPFEDSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 304182   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM304182 ((R)-4-[(2-{5-[3-chloro-6-(difluoromethoxy)-2-fluor...) Show SMILES OC(=O)c1ccc(NC(=O)[C@H](CC2CC2)c2ccc(c[n+]2[O-])-c2c(F)c(Cl)ccc2OC(F)F)cc1F |r| Show InChI InChI=1S/C25H19ClF4N2O5/c26-17-6-8-20(37-25(29)30)21(22(17)28)13-3-7-19(32(36)11-13)16(9-12-1-2-12)23(33)31-14-4-5-15(24(34)35)18(27)10-14/h3-8,10-12,16,25H,1-2,9H2,(H,31,33)(H,34,35)/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...				US Patent US10143681 (2018) BindingDB Entry DOI: 10.7270/Q2348NG3
					More data for this Ligand-Target Pair
Coagulation factor XI (Homo sapiens (Human))	BDBM304182 ((R)-4-[(2-{5-[3-chloro-6-(difluoromethoxy)-2-fluor...) Show SMILES OC(=O)c1ccc(NC(=O)[C@H](CC2CC2)c2ccc(c[n+]2[O-])-c2c(F)c(Cl)ccc2OC(F)F)cc1F |r| Show InChI InChI=1S/C25H19ClF4N2O5/c26-17-6-8-20(37-25(29)30)21(22(17)28)13-3-7-19(32(36)11-13)16(9-12-1-2-12)23(33)31-14-4-5-15(24(34)35)18(27)10-14/h3-8,10-12,16,25H,1-2,9H2,(H,31,33)(H,34,35)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...				US Patent US10143681 (2018) BindingDB Entry DOI: 10.7270/Q2348NG3
					More data for this Ligand-Target Pair