null

SMILES: Cc1ccc(F)cc1C(=O)NC1(C)CCN(CC1)c1ccc(cn1)-c1cc(O)cn2ncc(C#N)c12

InChI Key: InChIKey=JCMROOHKMOEILZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 305468   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305468 (US10144734, Example 485 | US10172845, Example 485 ...) Show SMILES Cc1ccc(F)cc1C(=O)NC1(C)CCN(CC1)c1ccc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C27H25FN6O2/c1-17-3-5-20(28)11-22(17)26(36)32-27(2)7-9-33(10-8-27)24-6-4-18(14-30-24)23-12-21(35)16-34-25(23)19(13-29)15-31-34/h3-6,11-12,14-16,35H,7-10H2,1-2H3,(H,32,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10144734 (2018) BindingDB Entry DOI: 10.7270/Q2251M8C
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M] (Homo sapiens (Human))	BDBM305468 (US10144734, Example 485 | US10172845, Example 485 ...) Show SMILES Cc1ccc(F)cc1C(=O)NC1(C)CCN(CC1)c1ccc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C27H25FN6O2/c1-17-3-5-20(28)11-22(17)26(36)32-27(2)7-9-33(10-8-27)24-6-4-18(14-30-24)23-12-21(35)16-34-25(23)19(13-29)15-31-34/h3-6,11-12,14-16,35H,7-10H2,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30.7	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10144734 (2018) BindingDB Entry DOI: 10.7270/Q2251M8C
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305468 (US10144734, Example 485 | US10172845, Example 485 ...) Show SMILES Cc1ccc(F)cc1C(=O)NC1(C)CCN(CC1)c1ccc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C27H25FN6O2/c1-17-3-5-20(28)11-22(17)26(36)32-27(2)7-9-33(10-8-27)24-6-4-18(14-30-24)23-12-21(35)16-34-25(23)19(13-29)15-31-34/h3-6,11-12,14-16,35H,7-10H2,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] (Homo sapiens (Human))	BDBM305468 (US10144734, Example 485 | US10172845, Example 485 ...) Show SMILES Cc1ccc(F)cc1C(=O)NC1(C)CCN(CC1)c1ccc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C27H25FN6O2/c1-17-3-5-20(28)11-22(17)26(36)32-27(2)7-9-33(10-8-27)24-6-4-18(14-30-24)23-12-21(35)16-34-25(23)19(13-29)15-31-34/h3-6,11-12,14-16,35H,7-10H2,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30.7	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M] (Homo sapiens (Human))	BDBM305468 (US10144734, Example 485 | US10172845, Example 485 ...) Show SMILES Cc1ccc(F)cc1C(=O)NC1(C)CCN(CC1)c1ccc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C27H25FN6O2/c1-17-3-5-20(28)11-22(17)26(36)32-27(2)7-9-33(10-8-27)24-6-4-18(14-30-24)23-12-21(35)16-34-25(23)19(13-29)15-31-34/h3-6,11-12,14-16,35H,7-10H2,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	30.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q21G0R6J
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [G810R] (Homo sapiens (Human))	BDBM305468 (US10144734, Example 485 | US10172845, Example 485 ...) Show SMILES Cc1ccc(F)cc1C(=O)NC1(C)CCN(CC1)c1ccc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C27H25FN6O2/c1-17-3-5-20(28)11-22(17)26(36)32-27(2)7-9-33(10-8-27)24-6-4-18(14-30-24)23-12-21(35)16-34-25(23)19(13-29)15-31-34/h3-6,11-12,14-16,35H,7-10H2,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30.7	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays contained...				US Patent US10441581 (2019) BindingDB Entry DOI: 10.7270/Q2DZ0BP3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305468 (US10144734, Example 485 | US10172845, Example 485 ...) Show SMILES Cc1ccc(F)cc1C(=O)NC1(C)CCN(CC1)c1ccc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C27H25FN6O2/c1-17-3-5-20(28)11-22(17)26(36)32-27(2)7-9-33(10-8-27)24-6-4-18(14-30-24)23-12-21(35)16-34-25(23)19(13-29)15-31-34/h3-6,11-12,14-16,35H,7-10H2,1-2H3,(H,32,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Wildtype and V804M mutant: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's ...				US Patent US10881652 (2021) BindingDB Entry DOI: 10.7270/Q2ZG6WBN
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M] (Homo sapiens (Human))	BDBM305468 (US10144734, Example 485 | US10172845, Example 485 ...) Show SMILES Cc1ccc(F)cc1C(=O)NC1(C)CCN(CC1)c1ccc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C27H25FN6O2/c1-17-3-5-20(28)11-22(17)26(36)32-27(2)7-9-33(10-8-27)24-6-4-18(14-30-24)23-12-21(35)16-34-25(23)19(13-29)15-31-34/h3-6,11-12,14-16,35H,7-10H2,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30.7	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Wildtype and V804M mutant: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's ...				US Patent US10881652 (2021) BindingDB Entry DOI: 10.7270/Q2ZG6WBN
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (aa658-end) (Homo sapiens (Human))	BDBM305468 (US10144734, Example 485 | US10172845, Example 485 ...) Show SMILES Cc1ccc(F)cc1C(=O)NC1(C)CCN(CC1)c1ccc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C27H25FN6O2/c1-17-3-5-20(28)11-22(17)26(36)32-27(2)7-9-33(10-8-27)24-6-4-18(14-30-24)23-12-21(35)16-34-25(23)19(13-29)15-31-34/h3-6,11-12,14-16,35H,7-10H2,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q21G0R6J
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] (Homo sapiens (Human))	BDBM305468 (US10144734, Example 485 | US10172845, Example 485 ...) Show SMILES Cc1ccc(F)cc1C(=O)NC1(C)CCN(CC1)c1ccc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C27H25FN6O2/c1-17-3-5-20(28)11-22(17)26(36)32-27(2)7-9-33(10-8-27)24-6-4-18(14-30-24)23-12-21(35)16-34-25(23)19(13-29)15-31-34/h3-6,11-12,14-16,35H,7-10H2,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10441581 (2019) BindingDB Entry DOI: 10.7270/Q2DZ0BP3
					More data for this Ligand-Target Pair