BDBM306113 US10144742, Compound I-275

SMILES: O=C(NCCCn1ccnc1)c1ccc2nc(N3CCC4(CC3)OCCO4)c(nc2c1)-c1ccccc1

InChI Key: InChIKey=BUXPQNNXPAQHLX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306113   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM306113 (US10144742, Compound I-275) Show SMILES O=C(NCCCn1ccnc1)c1ccc2nc(N3CCC4(CC3)OCCO4)c(nc2c1)-c1ccccc1 Show InChI InChI=1S/C28H30N6O3/c35-27(30-11-4-13-33-16-12-29-20-33)22-7-8-23-24(19-22)31-25(21-5-2-1-3-6-21)26(32-23)34-14-9-28(10-15-34)36-17-18-37-28/h1-3,5-8,12,16,19-20H,4,9-11,13-15,17-18H2,(H,30,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. US Patent					Assay Description To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...				US Patent US10144742 (2018) BindingDB Entry DOI: 10.7270/Q2NV9M91
					More data for this Ligand-Target Pair