BDBM307833 N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-2-(piperidin-4-yl)acetamide::US9650358, Example 129

SMILES: Fc1cccc(Cn2cnc3ccc(cc23)-c2cc(NC(=O)CC3CCNCC3)ncc2Cl)c1

InChI Key: InChIKey=YJAREEUXYBSYEQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 307833   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM307833 (N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-...) Show SMILES Fc1cccc(Cn2cnc3ccc(cc23)-c2cc(NC(=O)CC3CCNCC3)ncc2Cl)c1 Show InChI InChI=1S/C26H25ClFN5O/c27-22-14-30-25(32-26(34)11-17-6-8-29-9-7-17)13-21(22)19-4-5-23-24(12-19)33(16-31-23)15-18-2-1-3-20(28)10-18/h1-5,10,12-14,16-17,29H,6-9,11,15H2,(H,30,32,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...				US Patent US9650358 (2017) BindingDB Entry DOI: 10.7270/Q2057J0M
					More data for this Ligand-Target Pair