BDBM307953 N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-pyrrolo[3,2-b]pyridin-6-yl]pyridin-2-yl}-6-azaspiro[3.4]octan-2-amine::US9650358, Example 249

SMILES:

InChI Key: InChIKey=SRNNKTBFJNJOIZ-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 307953   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM307953 (N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-pyrrolo[3,2-b...) Show SMILES Show InChI InChI=1S/C26H25ClFN5/c27-22-14-31-25(32-20-11-26(12-20)5-6-29-16-26)10-21(22)18-9-24-23(30-13-18)4-7-33(24)15-17-2-1-3-19(28)8-17/h1-4,7-10,13-14,20,29H,5-6,11-12,15-16H2,(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...				US Patent US9650358 (2017) BindingDB Entry DOI: 10.7270/Q2057J0M
					More data for this Ligand-Target Pair