BDBM307980 N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-6-carboxamide::US9650358, Example 276

SMILES: Fc1cccc(Cn2cnc3ccc(cc23)-c2cc(NC(=O)C3CCc4nccn4C3)ncc2Cl)c1

InChI Key: InChIKey=ZILSMUPLGAMJHB-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 307980   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM307980 (N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-...) Show SMILES Fc1cccc(Cn2cnc3ccc(cc23)-c2cc(NC(=O)C3CCc4nccn4C3)ncc2Cl)c1 Show InChI InChI=1S/C27H22ClFN6O/c28-22-13-31-25(33-27(36)19-5-7-26-30-8-9-34(26)15-19)12-21(22)18-4-6-23-24(11-18)35(16-32-23)14-17-2-1-3-20(29)10-17/h1-4,6,8-13,16,19H,5,7,14-15H2,(H,31,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...				US Patent US9650358 (2017) BindingDB Entry DOI: 10.7270/Q2057J0M
					More data for this Ligand-Target Pair