BDBM308063 US10011593, Ex. 14::US9650366, 14

SMILES: Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1)-c1cnccn1

InChI Key: InChIKey=PIQFMVCIUBAYKI-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 308063   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interferon-induced, double-stranded RNA-activated protein kinase (Homo sapiens (Human))	BDBM308063 (US10011593, Ex. 14 | US9650366, 14) Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1)-c1cnccn1 Show InChI InChI=1S/C25H16ClF3N6OS/c26-19-3-1-16(10-18(19)25(27,28)29)35-24(36)34-15-2-4-21-13(7-15)9-22(37-21)17-8-14(11-33-23(17)30)20-12-31-5-6-32-20/h1-12H,(H2,30,33)(H2,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	301	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...				US Patent US9650366 (2017) BindingDB Entry DOI: 10.7270/Q2QN68VG
					More data for this Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase (Homo sapiens (Human))	BDBM308063 (US10011593, Ex. 14 | US9650366, 14) Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1)-c1cnccn1 Show InChI InChI=1S/C25H16ClF3N6OS/c26-19-3-1-16(10-18(19)25(27,28)29)35-24(36)34-15-2-4-21-13(7-15)9-22(37-21)17-8-14(11-33-23(17)30)20-12-31-5-6-32-20/h1-12H,(H2,30,33)(H2,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	301	n/a	n/a	n/a	n/a	n/a	n/a
Vertex					Assay Description PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...				J Med Chem 52: 6362-8 (2009) BindingDB Entry DOI: 10.7270/Q24J0HGV
					More data for this Ligand-Target Pair