BDBM311362 (S)-2,4-dimethyl-1-((5-(quinolin-4-yl)-3-(trifluoromethyl)pyridin-2-yl)oxy)pentan-2-amine::US10155760, Example 219::US10351563, Example 219::US10544120, Example 219::US10723734, Example 219::US10981910, Example 219::US9902722, Example 219

SMILES: CC(C)C[C@](C)(N)COc1ncc(cc1C(F)(F)F)-c1ccnc2ccccc12

InChI Key: InChIKey=DPRYJZGDMSIMLY-NRFANRHFSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 311362   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
AP2-associated protein kinase 1 (Homo sapiens (Human))	BDBM311362 ((S)-2,4-dimethyl-1-((5-(quinolin-4-yl)-3-(trifluor...) Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1C(F)(F)F)-c1ccnc2ccccc12 |r| Show InChI InChI=1S/C22H24F3N3O/c1-14(2)11-21(3,26)13-29-20-18(22(23,24)25)10-15(12-28-20)16-8-9-27-19-7-5-4-6-17(16)19/h4-10,12,14H,11,13,26H2,1-3H3/t21-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...				US Patent US10155760 (2018) BindingDB Entry DOI: 10.7270/Q2F191S4
					More data for this Ligand-Target Pair
AP2-associated protein kinase 1 (Homo sapiens (Human))	BDBM311362 ((S)-2,4-dimethyl-1-((5-(quinolin-4-yl)-3-(trifluor...) Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1C(F)(F)F)-c1ccnc2ccccc12 |r| Show InChI InChI=1S/C22H24F3N3O/c1-14(2)11-21(3,26)13-29-20-18(22(23,24)25)10-15(12-28-20)16-8-9-27-19-7-5-4-6-17(16)19/h4-10,12,14H,11,13,26H2,1-3H3/t21-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2930WGG
					More data for this Ligand-Target Pair
AP2-associated protein kinase 1 (Homo sapiens (Human))	BDBM311362 ((S)-2,4-dimethyl-1-((5-(quinolin-4-yl)-3-(trifluor...) Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1C(F)(F)F)-c1ccnc2ccccc12 |r| Show InChI InChI=1S/C22H24F3N3O/c1-14(2)11-21(3,26)13-29-20-18(22(23,24)25)10-15(12-28-20)16-8-9-27-19-7-5-4-6-17(16)19/h4-10,12,14H,11,13,26H2,1-3H3/t21-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...				US Patent US10981910 (2021)
					More data for this Ligand-Target Pair
AP2-associated protein kinase 1 (Homo sapiens (Human))	BDBM311362 ((S)-2,4-dimethyl-1-((5-(quinolin-4-yl)-3-(trifluor...) Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1C(F)(F)F)-c1ccnc2ccccc12 |r| Show InChI InChI=1S/C22H24F3N3O/c1-14(2)11-21(3,26)13-29-20-18(22(23,24)25)10-15(12-28-20)16-8-9-27-19-7-5-4-6-17(16)19/h4-10,12,14H,11,13,26H2,1-3H3/t21-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...				US Patent US10544120 (2020) BindingDB Entry DOI: 10.7270/Q2RF5XCX
					More data for this Ligand-Target Pair
AP2-associated protein kinase 1 (Homo sapiens (Human))	BDBM311362 ((S)-2,4-dimethyl-1-((5-(quinolin-4-yl)-3-(trifluor...) Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1C(F)(F)F)-c1ccnc2ccccc12 |r| Show InChI InChI=1S/C22H24F3N3O/c1-14(2)11-21(3,26)13-29-20-18(22(23,24)25)10-15(12-28-20)16-8-9-27-19-7-5-4-6-17(16)19/h4-10,12,14H,11,13,26H2,1-3H3/t21-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 Cl prepared from 15 μl additions of enzyme and substrates (...				US Patent US10723734 (2020)
					More data for this Ligand-Target Pair
AP2-associated protein kinase 1 (Homo sapiens (Human))	BDBM311362 ((S)-2,4-dimethyl-1-((5-(quinolin-4-yl)-3-(trifluor...) Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1C(F)(F)F)-c1ccnc2ccccc12 |r| Show InChI InChI=1S/C22H24F3N3O/c1-14(2)11-21(3,26)13-29-20-18(22(23,24)25)10-15(12-28-20)16-8-9-27-19-7-5-4-6-17(16)19/h4-10,12,14H,11,13,26H2,1-3H3/t21-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...				US Patent US10351563 (2019) BindingDB Entry DOI: 10.7270/Q2P55QWS
					More data for this Ligand-Target Pair