BDBM311451 CHEM-US-00148::US10155764, Example 37

SMILES: CN(C)C(CNc1nn(C)c(=O)c2CCCc12)c1ccccc1

InChI Key: InChIKey=DXMZXPQSSCKUSZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 311451   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone acetyltransferase KAT2B [719-832] (Homo sapiens (Human))	BDBM311451 (CHEM-US-00148 | US10155764, Example 37) Show SMILES CN(C)C(CNc1nn(C)c(=O)c2CCCc12)c1ccccc1 Show InChI InChI=1S/C18H24N4O/c1-21(2)16(13-8-5-4-6-9-13)12-19-17-14-10-7-11-15(14)18(23)22(3)20-17/h4-6,8-9,16H,7,10-12H2,1-3H3,(H,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...				US Patent US10155764 (2018) BindingDB Entry DOI: 10.7270/Q25M67T9
					More data for this Ligand-Target Pair