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SMILES: NC(=N)NCCC[C@@H]1NC(=O)\C=C\C(=O)NC(CCCCCC(=O)C(Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)CC1=O)C(N)=O

InChI Key: InChIKey=DGPPDZULLUUWNA-GRNYFAIRSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 314087   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Insulin-degrading enzyme


(Homo sapiens (Human))		BDBM314087
PNG
(US9610322, 2 (cis olefin))
Show SMILES NC(=N)NCCC[C@@H]1NC(=O)\C=C\C(=O)NC(CCCCCC(=O)C(Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)CC1=O)C(N)=O |r,t:11|
Show InChI InChI=1S/C43H57N7O7/c44-41(56)34-15-8-3-9-17-36(51)35(26-29-18-20-31(21-19-29)40(55)30-13-6-2-7-14-30)50-42(57)32(25-28-11-4-1-5-12-28)27-37(52)33(16-10-24-47-43(45)46)48-38(53)22-23-39(54)49-34/h2,6-7,13-14,18-23,28,32-35H,1,3-5,8-12,15-17,24-27H2,(H2,44,56)(H,48,53)(H,49,54)(H,50,57)(H4,45,46,47)/b23-22+/t32-,33+,34?,35?/m1/s1
PDB
MMDB

KEGG

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PC cid
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UniChem
US Patent
n/an/a 1.00E+4n/an/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
In vitro protease assays: Protease assays with IDE and neprilysin were performed using Mca-RPPGFSAFK(Dnp)-OH substrate peptide (R&D Systems, SEQ ID N...

US Patent US9610322 (2017)


BindingDB Entry DOI: 10.7270/Q29Z970C
More data for this
Ligand-Target Pair