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SMILES: Cc1c(nc2c(C)cc(nn12)C#Cc1nc(nn1C)N1CCCC1)C(F)(F)F

InChI Key: InChIKey=PPPPMCPCFDIGGO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 317196   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM317196
PNG
(3,8-Dimethyl-6-((1-methyl-3-(pyrrolidin-1-yl)-1H-1...)
Show SMILES Cc1c(nc2c(C)cc(nn12)C#Cc1nc(nn1C)N1CCCC1)C(F)(F)F
Show InChI InChI=1S/C18H18F3N7/c1-11-10-13(24-28-12(2)15(18(19,20)21)23-16(11)28)6-7-14-22-17(25-26(14)3)27-8-4-5-9-27/h10H,4-5,8-9H2,1-3H3
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 1.60n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM...

US Patent US9617271 (2017)


BindingDB Entry DOI: 10.7270/Q2N58PFC
More data for this
Ligand-Target Pair