null

SMILES: Cc1noc(C)c1-c1ccc2nc(N3CC[C@@H](O)C3)n3C(COc1c23)c1cccnc1

InChI Key: InChIKey=ZDSYNVSABAYEKF-VTBWFHPJSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 318618   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 [342-460] (Homo sapiens (Human))	BDBM318618 ((3R)-1-[7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-3-...) Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CC[C@@H](O)C3)n3C(COc1c23)c1cccnc1 |r,wU:16.17,(-1.8,-6.16,;-3.14,-5.39,;-4.6,-5.87,;-5.51,-4.62,;-4.6,-3.37,;-5.37,-2.04,;-3.14,-3.85,;-1.8,-3.08,;-.47,-3.85,;.86,-3.08,;.86,-1.54,;2.2,-.77,;1.39,.87,;2.16,2.21,;1.68,3.67,;2.93,4.58,;4.17,3.67,;5.51,4.44,;3.7,2.21,;-.47,.77,;-1.8,1.54,;-3.14,.77,;-3.14,-.77,;-1.8,-1.54,;-.47,-.77,;-1.8,3.08,;-3.14,3.85,;-3.14,5.39,;-1.8,6.16,;-.47,5.39,;-.47,3.85,)| Show InChI InChI=1S/C23H23N5O3/c1-13-20(14(2)31-26-13)17-5-6-18-21-22(17)30-12-19(15-4-3-8-24-10-15)28(21)23(25-18)27-9-7-16(29)11-27/h3-6,8,10,16,19,29H,7,9,11-12H2,1-2H3/t16-,19?/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...				US Patent US9624241 (2017) BindingDB Entry DOI: 10.7270/Q2NZ89QB
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM318618 ((3R)-1-[7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-3-...) Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CC[C@@H](O)C3)n3C(COc1c23)c1cccnc1 |r,wU:16.17,(-1.8,-6.16,;-3.14,-5.39,;-4.6,-5.87,;-5.51,-4.62,;-4.6,-3.37,;-5.37,-2.04,;-3.14,-3.85,;-1.8,-3.08,;-.47,-3.85,;.86,-3.08,;.86,-1.54,;2.2,-.77,;1.39,.87,;2.16,2.21,;1.68,3.67,;2.93,4.58,;4.17,3.67,;5.51,4.44,;3.7,2.21,;-.47,.77,;-1.8,1.54,;-3.14,.77,;-3.14,-.77,;-1.8,-1.54,;-.47,-.77,;-1.8,3.08,;-3.14,3.85,;-3.14,5.39,;-1.8,6.16,;-.47,5.39,;-.47,3.85,)| Show InChI InChI=1S/C23H23N5O3/c1-13-20(14(2)31-26-13)17-5-6-18-21-22(17)30-12-19(15-4-3-8-24-10-15)28(21)23(25-18)27-9-7-16(29)11-27/h3-6,8,10,16,19,29H,7,9,11-12H2,1-2H3/t16-,19?/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...				US Patent US9624241 (2017) BindingDB Entry DOI: 10.7270/Q2NZ89QB
					More data for this Ligand-Target Pair