BDBM318866 N-(3-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)acrylamide::US10172868, Compound C001::US10653701, Compound C001

SMILES: C=CC(=O)Nc1cccc(c1)-c1cccc2cnc(Nc3ccc(cc3)N3CCOCC3)nc12

InChI Key: InChIKey=UGBCGKJUUJFYHF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 318866   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	BDBM318866 (N-(3-(2-((4-morpholinophenyl)amino)quinazolin-8-yl...) Show SMILES C=CC(=O)Nc1cccc(c1)-c1cccc2cnc(Nc3ccc(cc3)N3CCOCC3)nc12 Show InChI InChI=1S/C27H25N5O2/c1-2-25(33)29-22-7-3-5-19(17-22)24-8-4-6-20-18-28-27(31-26(20)24)30-21-9-11-23(12-10-21)32-13-15-34-16-14-32/h2-12,17-18H,1,13-16H2,(H,29,33)(H,28,30,31)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
NEUPHARMA, INC. US Patent					Assay Description The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...				US Patent US10172868 (2019) BindingDB Entry DOI: 10.7270/Q25141BX
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	US11304957, Compound C001 (N-(3-(2-((4-morpholinophenyl)amino)quinazolin-8-yl...) Show SMILES C=CC(=O)Nc1cccc(c1)-c1cccc2cnc(Nc3ccc(cc3)N3CCOCC3)nc12 Show InChI InChI=1S/C27H25N5O2/c1-2-25(33)29-22-7-3-5-19(17-22)24-8-4-6-20-18-28-27(31-26(20)24)30-21-9-11-23(12-10-21)32-13-15-34-16-14-32/h2-12,17-18H,1,13-16H2,(H,29,33)(H,28,30,31)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	BDBM318866 (N-(3-(2-((4-morpholinophenyl)amino)quinazolin-8-yl...) Show SMILES C=CC(=O)Nc1cccc(c1)-c1cccc2cnc(Nc3ccc(cc3)N3CCOCC3)nc12 Show InChI InChI=1S/C27H25N5O2/c1-2-25(33)29-22-7-3-5-19(17-22)24-8-4-6-20-18-28-27(31-26(20)24)30-21-9-11-23(12-10-21)32-13-15-34-16-14-32/h2-12,17-18H,1,13-16H2,(H,29,33)(H,28,30,31)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
NEUPHARMA, INC. US Patent					Assay Description (i) Peptide/Kinase Mixtures for measurement of EGFR (ErbB1):The 2×EGFR (ErbB1)/Tyr 04 mixture is prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM...				US Patent US10653701 (2020)
					More data for this Ligand-Target Pair