BDBM319485 US10173991, Example 541::propan-2-yl N-{4- [2-({[(cyclopropyl- carbamoyl)methyl] carbamoyl} (propane-2-sulfonyl) methyl)-5-fluoro- 1,3-benzothiazol- 6-yl]phenyl} carbamate

SMILES: CC(C)OC(=O)Nc1ccc(cc1)-c1cc2sc(nc2cc1F)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)C(C)C

InChI Key: InChIKey=HKPYPPPFVFWGIQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 319485   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Homo sapiens (Human))	BDBM319485 (US10173991, Example 541 | propan-2-yl N-{4- [2-({[...) Show SMILES CC(C)OC(=O)Nc1ccc(cc1)-c1cc2sc(nc2cc1F)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)C(C)C Show InChI InChI=1S/C27H31FN4O6S2/c1-14(2)38-27(35)31-18-7-5-16(6-8-18)19-11-22-21(12-20(19)28)32-26(39-22)24(40(36,37)15(3)4)25(34)29-13-23(33)30-17-9-10-17/h5-8,11-12,14-15,17,24H,9-10,13H2,1-4H3,(H,29,34)(H,30,33)(H,31,35)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...				US Patent US10173991 (2019) BindingDB Entry DOI: 10.7270/Q2N018M8
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