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SMILES: Cc1nnc([nH]1)-n1ccc2cc(ccc12)N1CCOc2ncnc(N)c2C1=O

InChI Key: InChIKey=LRASAEHPLPIYQW-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 321168   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM321168 (US10174049, Example 35 | US9738658, Example 35 | U...) Show SMILES Cc1nnc([nH]1)-n1ccc2cc(ccc12)N1CCOc2ncnc(N)c2C1=O Show InChI InChI=1S/C18H16N8O2/c1-10-22-18(24-23-10)26-5-4-11-8-12(2-3-13(11)26)25-6-7-28-16-14(17(25)27)15(19)20-9-21-16/h2-5,8-9H,6-7H2,1H3,(H2,19,20,21)(H,22,23,24)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Glaxosmithkline LLC US Patent					Assay Description For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...				US Patent US10174049 (2019) BindingDB Entry DOI: 10.7270/Q2X92DCR
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM321168 (US10174049, Example 35 | US9738658, Example 35 | U...) Show SMILES Cc1nnc([nH]1)-n1ccc2cc(ccc12)N1CCOc2ncnc(N)c2C1=O Show InChI InChI=1S/C18H16N8O2/c1-10-22-18(24-23-10)26-5-4-11-8-12(2-3-13(11)26)25-6-7-28-16-14(17(25)27)15(19)20-9-21-16/h2-5,8-9H,6-7H2,1H3,(H2,19,20,21)(H,22,23,24)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE LLC US Patent					Assay Description For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...				US Patent US9796729 (2017) BindingDB Entry DOI: 10.7270/Q2057J2H
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM321168 (US10174049, Example 35 | US9738658, Example 35 | U...) Show SMILES Cc1nnc([nH]1)-n1ccc2cc(ccc12)N1CCOc2ncnc(N)c2C1=O Show InChI InChI=1S/C18H16N8O2/c1-10-22-18(24-23-10)26-5-4-11-8-12(2-3-13(11)26)25-6-7-28-16-14(17(25)27)15(19)20-9-21-16/h2-5,8-9H,6-7H2,1H3,(H2,19,20,21)(H,22,23,24)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline LLC US Patent					Assay Description For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...				US Patent US9738658 (2017) BindingDB Entry DOI: 10.7270/Q26Q20BZ
					More data for this Ligand-Target Pair