BDBM321348 3-({[(1R)-6-methoxy-1,2,3,4- tetrahydronaphthalen-1-yl]-methyl} amino)pyridine-4-carboxylic acid::US10179769, Example 62::US10807956, Example 62
SMILES: COc1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1
InChI Key: InChIKey=NXQKMWGCRMQRSS-ZDUSSCGKSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Lysine-specific demethylase 5B (Homo sapiens (Human)) | BDBM321348![]() (3-({[(1R)-6-methoxy-1,2,3,4- tetrahydronaphthalen-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ... | US Patent US10179769 (2019) BindingDB Entry DOI: 10.7270/Q2J38VPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM321348![]() (3-({[(1R)-6-methoxy-1,2,3,4- tetrahydronaphthalen-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | n/a | n/a | 560 | n/a | n/a | n/a | n/a |
Celgene Quanticel Research Curated by ChEMBL | Assay Description Inhibition of full-length KDM4C (unknown origin) expressed in human KYSE-150 cells assessed as increase in H3K36me3 level after 24 hrs by Western blo... | ACS Med Chem Lett 8: 869-874 (2017) Article DOI: 10.1021/acsmedchemlett.7b00220 BindingDB Entry DOI: 10.7270/Q2HH6NPJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM321348![]() (3-({[(1R)-6-methoxy-1,2,3,4- tetrahydronaphthalen-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM321348![]() (3-({[(1R)-6-methoxy-1,2,3,4- tetrahydronaphthalen-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
CELGENE QUANTICEL RESEARCH, INC. US Patent | Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ... | US Patent US10807956 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM321348![]() (3-({[(1R)-6-methoxy-1,2,3,4- tetrahydronaphthalen-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research Curated by ChEMBL | Assay Description Inhibition of KDM4C (unknown origin) using biotinylated H3K9me3 peptide and alpha-ketoglutarate as substrate pretreated for 1 hr followed by substrat... | ACS Med Chem Lett 8: 869-874 (2017) Article DOI: 10.1021/acsmedchemlett.7b00220 BindingDB Entry DOI: 10.7270/Q2HH6NPJ | |||||||||||
More data for this Ligand-Target Pair |